Acute Lymphoblastic Leukemia-associated JAK1 Mutants Activate the Janus Kinase/STAT Pathway via Interleukin-9 Receptor α Homodimers

Activating mutations in JAK1 have been reported in acute lymphoblastic leukemias, but little is known about the mechanisms involved in their constitutive activation. Here, we studied the ability of JAK1 V658F and A634D to activate the Janus kinase (JAK)/STAT pathway upon ectopic expression in HEK293...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Hornakova, Tekla, Staerk, Judith, Royer, Yohan, Flex, Elisabetta, Tartaglia, Marco, Constantinescu, Stefan N., Knoops, Laurent, Renauld, Jean-Christophe
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2009
Gaiak:
Mechanisms of Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652315/
https://ncbi.nlm.nih.gov/pubmed/19139102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807531200
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