Distinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities

JAK1 and JAK3 are recurrently mutated in acute lymphoblastic leukemia. These tyrosine kinases associate with heterodimeric cytokine receptors such as IL-7 receptor or IL-9 receptor, in which JAK1 is appended to the specific chain, and JAK3 is appended to the common gamma chain. Here, we studied the...

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Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Losdyck, Elisabeth, Hornakova, Tekla, Springuel, Lorraine, Degryse, Sandrine, Gielen, Olga, Cools, Jan, Constantinescu, Stefan N., Flex, Elisabetta, Tartaglia, Marco, Renauld, Jean-Christophe, Knoops, Laurent
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2015
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661414/
https://ncbi.nlm.nih.gov/pubmed/26446793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.670224
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