Acute Lymphoblastic Leukemia-associated JAK1 Mutants Activate the Janus Kinase/STAT Pathway via Interleukin-9 Receptor α Homodimers

Activating mutations in JAK1 have been reported in acute lymphoblastic leukemias, but little is known about the mechanisms involved in their constitutive activation. Here, we studied the ability of JAK1 V658F and A634D to activate the Janus kinase (JAK)/STAT pathway upon ectopic expression in HEK293...

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Detalhes bibliográficos
Main Authors: Hornakova, Tekla, Staerk, Judith, Royer, Yohan, Flex, Elisabetta, Tartaglia, Marco, Constantinescu, Stefan N., Knoops, Laurent, Renauld, Jean-Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652315/
https://ncbi.nlm.nih.gov/pubmed/19139102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807531200
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