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Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia
Aberrant signal transduction contributes substantially to leukemogenesis. The Janus kinase 1 (JAK1) gene encodes a cytoplasmic tyrosine kinase that noncovalently associates with a variety of cytokine receptors and plays a nonredundant role in lymphoid cell precursor proliferation, survival, and diff...
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Autori principali: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
The Rockefeller University Press
2008
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Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2292215/ https://ncbi.nlm.nih.gov/pubmed/18362173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20072182 |
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