Primary and Secondary Kinase Genotypes Correlate With the Biological and Clinical Activity of Sunitinib in Imatinib-Resistant Gastrointestinal Stromal Tumor

PURPOSE: Most gastrointestinal stromal tumors (GISTs) harbor mutant KIT or platelet-derived growth factor receptor α (PDGFRA) kinases, which are imatinib targets. Sunitinib, which targets KIT, PDGFRs, and several other kinases, has demonstrated efficacy in patients with GIST after they experience im...

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Détails bibliographiques
Auteurs principaux: Heinrich, Michael C., Maki, Robert G., Corless, Christopher L., Antonescu, Cristina R., Harlow, Amy, Griffith, Diana, Town, Ajia, Mckinley, Arin, Ou, Wen-Bin, Fletcher, Jonathan A., Fletcher, Christopher D.M., Huang, Xin, Cohen, Darrel P., Baum, Charles M., Demetri, George D.
Format: Artigo
Langue:Inglês
Publié: American Society of Clinical Oncology 2008
Sujets:
Sarcomas
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651076/
https://ncbi.nlm.nih.gov/pubmed/18955458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2007.15.7461
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