Primary and Secondary Kinase Genotypes Correlate With the Biological and Clinical Activity of Sunitinib in Imatinib-Resistant Gastrointestinal Stromal Tumor

PURPOSE: Most gastrointestinal stromal tumors (GISTs) harbor mutant KIT or platelet-derived growth factor receptor α (PDGFRA) kinases, which are imatinib targets. Sunitinib, which targets KIT, PDGFRs, and several other kinases, has demonstrated efficacy in patients with GIST after they experience im...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Heinrich, Michael C., Maki, Robert G., Corless, Christopher L., Antonescu, Cristina R., Harlow, Amy, Griffith, Diana, Town, Ajia, Mckinley, Arin, Ou, Wen-Bin, Fletcher, Jonathan A., Fletcher, Christopher D.M., Huang, Xin, Cohen, Darrel P., Baum, Charles M., Demetri, George D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Clinical Oncology 2008
Ämnen:
Sarcomas
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651076/
https://ncbi.nlm.nih.gov/pubmed/18955458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2007.15.7461
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk