Molecular Target Modulation, Imaging, and Clinical Evaluation of Gastrointestinal Stromal Tumor Patients Treated with Sunitinib Malate after Imatinib Failure

PURPOSE: To evaluate sunitinib activity and potential cellular and molecular correlates in gastrointestinal stromal tumor (GIST) patients after imatinib failure, in addition to assessing the safety and pharmacokinetics (PK) of different dose schedules. EXPERIMENTAL DESIGN: In this open-label, dose-r...

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Bibliografiska uppgifter
Huvudupphovsmän: Demetri, George D., Heinrich, Michael C., Fletcher, Jonathan A., Fletcher, Christopher D.M., Van den Abbeele, Annick D., Corless, Christopher L., Antonescu, Cristina R., George, Suzanne, Morgan, Jeffrey A., Chen, Ming Hui, Bello, Carlo L., Huang, Xin, Cohen, Darrel P., Baum, Charles M., Maki, Robert G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417101/
https://ncbi.nlm.nih.gov/pubmed/19737946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0482
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