Correlation of Kinase Genotype and Clinical Outcome in the North American Intergroup Phase III Trial of Imatinib Mesylate for Treatment of Advanced Gastrointestinal Stromal Tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group

PURPOSE: Imatinib mesylate is standard treatment for patients who have advanced gastrointestinal stromal tumor (GIST), but not all patients benefit equally. In previous studies, GIST genotype correlated with treatment outcome and optimal imatinib dosing. PATIENTS AND METHODS: We examined the relatio...

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Detalhes bibliográficos
Main Authors: Heinrich, Michael C., Owzar, Kouros, Corless, Christopher L., Hollis, Donna, Borden, Ernest C., Fletcher, Christopher D.M., Ryan, Christopher W., von Mehren, Margaret, Blanke, Charles D., Rankin, Cathryn, Benjamin, Robert S., Bramwell, Vivien H., Demetri, George D., Bertagnolli, Monica M., Fletcher, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651078/
https://ncbi.nlm.nih.gov/pubmed/18955451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.17.4284
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