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Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803

PURPOSE: Alterations in the RAS-RAF-MAP2K (MEK)-MAPK signaling pathway are major drivers in colon and rectal carcinogenesis. In colorectal cancer, BRAF mutation is associated with microsatellite instability (MSI), and typically predicts inferior prognosis. We examined the effect of BRAF mutation on...

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Κύριοι συγγραφείς:	Ogino, Shuji, Shima, Kaori, Meyerhardt, Jeffrey A., McCleary, Nadine J., Ng, Kimmie, Hollis, Donna, Saltz, Leonard B., Mayer, Robert J., Schaefer, Paul, Whittom, Renaud, Hantel, Alexander, Benson, Al B., Spiegelman, Donna, Goldberg, Richard M., Bertagnolli, Monica M., Fuchs, Charles S.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	2011
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3271172/ https://ncbi.nlm.nih.gov/pubmed/22147942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2246
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Predictive and Prognostic Roles of BRAF Mutation in Stage III Colon Cancer: Results from Intergroup Trial CALGB 89803

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