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Active site substitutions delineate distinct classes of eubacterial flap endonuclease

FENs (flap endonucleases) play essential roles in DNA replication, pivotally in the resolution of Okazaki fragments. In eubacteria, DNA PolI (polymerase I) contains a flap processing domain, the N-terminal 5′→3′ exonuclease. We present evidence of paralogous FEN-encoding genes present in many eubact...

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Bibliografski detalji
Glavni autori: Allen, Lee M., Hodskinson, Michael R. G., Sayers, Jon R.
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650880/
https://ncbi.nlm.nih.gov/pubmed/19000038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20081637
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