Direct observation of DNA threading in flap endonuclease complexes

Maintenance of genome integrity requires that branched nucleic acid molecules are accurately processed to produce double-helical DNA. Flap endonucleases are essential enzymes that trim such branched molecules generated by Okazaki fragment synthesis during replication. Here, we report crystal structu...

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Publicado en:Nat Struct Mol Biol
Autores principales: AlMalki, Faizah A, Flemming, Claudia S, Zhang, Jing, Feng, Min, Sedelnikova, Svetlana E, Ceska, Tom, Rafferty, John B, Sayers, Jon R, Artymiuk, Peter J
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939078/
https://ncbi.nlm.nih.gov/pubmed/27273516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3241
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