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Flap Endonuclease 1 Mechanism Analysis Indicates Flap Base Binding Prior to Threading

FEN1 cleaves 5′ flaps at their base to create a nicked product for ligation. FEN1 has been reported to enter the flap from the 5′-end and track to the base. Current binding analyses support a very different mechanism of interaction with the flap substrate. Measurements of FEN1 binding to a flap subs...

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Bibliografiske detaljer
Main Authors: Gloor, Jason W., Balakrishnan, Lata, Bambara, Robert A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2966106/
https://ncbi.nlm.nih.gov/pubmed/20739288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165902
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