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Flap Endonuclease 1 Mechanism Analysis Indicates Flap Base Binding Prior to Threading
FEN1 cleaves 5′ flaps at their base to create a nicked product for ligation. FEN1 has been reported to enter the flap from the 5′-end and track to the base. Current binding analyses support a very different mechanism of interaction with the flap substrate. Measurements of FEN1 binding to a flap subs...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2966106/ https://ncbi.nlm.nih.gov/pubmed/20739288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165902 |
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