Acetylation of Dna2 Endonuclease/Helicase and Flap Endonuclease 1 by p300 Promotes DNA Stability by Creating Long Flap Intermediates

Flap endonuclease 1 (FEN1) and Dna2 endonuclease/helicase (Dna2) sequentially coordinate their nuclease activities for efficient resolution of flap structures that are created during the maturation of Okazaki fragments and repair of DNA damage. Acetylation of FEN1 by p300 inhibits its endonuclease a...

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Bibliographic Details
Main Authors: Balakrishnan, Lata, Stewart, Jason, Polaczek, Piotr, Campbell, Judith L., Bambara, Robert A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836044/
https://ncbi.nlm.nih.gov/pubmed/20019387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.086397
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