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Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP
Functional inactivation of p53 and constitutive activation of the NF-κB pathway has been associated with several human cancers. In this study, we show that IκB kinase 2 (IKK2/IKKβ), which is critical for NF-κB activation, also phosphorylates p53. Phosphorylation of p53 at serines 362 and 366 by IKK2...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650315/ https://ncbi.nlm.nih.gov/pubmed/19196987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812256106 |
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