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IκB Kinase-Independent IκBα Degradation Pathway: Functional NF-κB Activity and Implications for Cancer Therapy

Antiapoptotic activity of NF-κB in tumors contributes to acquisition of resistance to chemotherapy. Degradation of IκB is a seminal step in activation of NF-κB. The IκB kinases, IKK1 and IKK2, have been implicated in both IκB degradation and subsequent modifications of NFκB. Using mouse embryo fibro...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Tergaonkar, Vinay, Bottero, Virginie, Ikawa, Masahito, Li, Qiutang, Verma, Inder M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2003
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262380/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14585967/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.22.8070-8083.2003
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