IκB Kinase-Independent IκBα Degradation Pathway: Functional NF-κB Activity and Implications for Cancer Therapy

Antiapoptotic activity of NF-κB in tumors contributes to acquisition of resistance to chemotherapy. Degradation of IκB is a seminal step in activation of NF-κB. The IκB kinases, IKK1 and IKK2, have been implicated in both IκB degradation and subsequent modifications of NFκB. Using mouse embryo fibro...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Tergaonkar, Vinay, Bottero, Virginie, Ikawa, Masahito, Li, Qiutang, Verma, Inder M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262380/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14585967/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.22.8070-8083.2003
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