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IκB Kinase-Independent IκBα Degradation Pathway: Functional NF-κB Activity and Implications for Cancer Therapy

Antiapoptotic activity of NF-κB in tumors contributes to acquisition of resistance to chemotherapy. Degradation of IκB is a seminal step in activation of NF-κB. The IκB kinases, IKK1 and IKK2, have been implicated in both IκB degradation and subsequent modifications of NFκB. Using mouse embryo fibro...

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Bibliografski detalji
Izdano u:Mol Cell Biol
Glavni autori: Tergaonkar, Vinay, Bottero, Virginie, Ikawa, Masahito, Li, Qiutang, Verma, Inder M.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2003
Teme:
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC262380/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14585967/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.22.8070-8083.2003
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