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The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo
c-Src kinase is a rate-limiting activator of osteoclast (OC) function and Src inhibitors are therefore candidate antiosteoporosis drugs. By affecting αvβ3 and macrophage-colony stimulating factor (M-CSF)-induced signaling, c-Src is central to osteoclast activity, but not differentiation. We find Lyn...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650155/ https://ncbi.nlm.nih.gov/pubmed/19171907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806963106 |
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