The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn

IgE/antigen-dependent mast cell activation plays a central role in immediate hypersensitivity and other allergic reactions. The Src family tyrosine kinase (SFK) Lyn is activated by the cross-linking of high-affinity IgE receptors (FcϵRI). Activated Lyn phosphorylates the FcϵRI subunits, β and γ, lea...

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Detalhes bibliográficos
Main Authors: Hong, Hong, Kitaura, Jiro, Xiao, Wenbin, Horejsi, Vaclav, Ra, Chisei, Lowell, Clifford A., Kawakami, Yuko, Kawakami, Toshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1988937/
https://ncbi.nlm.nih.gov/pubmed/17513616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-066092
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