Positive and Negative Regulation of Mast Cell Activation by Lyn via the Fc∊RI

Aggregation of the high affinity receptor for IgE (Fc∊RI) induces activation of mast cells. In this study we show that upon low intensity stimulation of Fc∊RI with monomeric IgE, IgE plus anti-IgE, or IgE plus low Ag, Lyn (a Src family kinase) positively regulates degranulation, cytokine production,...

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Autori principali: Xiao, Wenbin, Nishimoto, Hajime, Hong, Hong, Kitaura, Jiro, Nunomura, Satoshi, Maeda-Yamamoto, Mari, Kawakami, Yuko, Lowell, Clifford A., Ra, Chisei, Kawakami, Toshiaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1415265/
https://ncbi.nlm.nih.gov/pubmed/16272347
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