Phospholipase C-β3 regulates FcεRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1

Mast cells are major effectors in high-affinity IgE receptor (FcεRI)-dependent allergic reactions. Here we show that phospholipase C (PLC)-β3 is crucial for FcεRI-mediated mast cell activation. Plcb3(−/−) mice showed blunted FcεRI-dependent late-phase, but not acute, anaphylactic responses and airwa...

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Detalhes bibliográficos
Main Authors: Xiao, Wenbin, Kashiwakura, Jun-ichi, Hong, Hong, Yasudo, Hiroki, Ando, Tomoaki, Maeda-Yamamoto, Mari, Wu, Dianqing, Kawakami, Yuko, Kawakami, Toshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124618/
https://ncbi.nlm.nih.gov/pubmed/21683628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.04.010
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