The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivo

c-Src kinase is a rate-limiting activator of osteoclast (OC) function and Src inhibitors are therefore candidate antiosteoporosis drugs. By affecting αvβ3 and macrophage-colony stimulating factor (M-CSF)-induced signaling, c-Src is central to osteoclast activity, but not differentiation. We find Lyn...

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Detaylı Bibliyografya
Asıl Yazarlar: Kim, Hyun-Ju, Zhang, Kaihua, Zhang, Lihong, Ross, F. Patrick, Teitelbaum, Steven L., Faccio, Roberta
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650155/
https://ncbi.nlm.nih.gov/pubmed/19171907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806963106
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