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Coordination changes and auto-hydroxylation of FIH-1: uncoupled O(2)-activation in a human hypoxia sensor

Hypoxia sensing is the generic term for pO(2)-sensing in humans and other higher organisms. These cellular responses to pO(2) are largely controlled by enzymes that belong to the Fe(II) α-ketoglutarate (αKG) dependent dioxygenase superfamily, including the human enzyme called the Factor Inhibiting H...

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Autors principals: Chen, Yuan-Han, Comeaux, Lindsay M., Herbst, Robert W., Saban, Evren, Kennedy, David C., Maroney, Michael J., Knapp, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649026/
https://ncbi.nlm.nih.gov/pubmed/18805587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2008.07.018
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