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Uncoupled O(2)-activation in the human HIF-asparaginyl hydroxylase, FIH, does not produce reactive oxygen species
The factor inhibiting HIF (FIH) is one of the primary oxygen sensors in human cells, controlling gene expression by hydroxylating the α-subunit of the hypoxia inducible transcription factor (HIF). As FIH is an alpha-ketoglutarate dependent non-heme iron dioxygenase, oxygen activation is thought to p...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3081918/ https://ncbi.nlm.nih.gov/pubmed/21443853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2011.01.007 |
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