The asparaginyl hydroxylase FIH (Factor Inhibiting HIF) is an essential regulator of metabolism

Factor Inhibiting HIF-1α (FIH) is an asparaginal hydroxylase. Hydroxylation of HIF-α proteins by FIH blocks association of HIFs with the transcriptional co-activators CBP/p300, thus inhibiting transcriptional activation. We have created mice with a null mutation in the FIH gene, and found that it ha...

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Hauptverfasser: Zhang, Na, Fu, Zhenxing, Linke, Sarah, Chicher, Johana, Gorman, Jeffrey J, Visk, DeeAnn, Haddad, Gabriel G., Poellinger, Lorenz, Peet, Daniel J, Powell, Frank, Johnson, Randall S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893150/
https://ncbi.nlm.nih.gov/pubmed/20399150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.03.001
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