The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia

Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The factor inhibiting HIF (FIH) is an asparaginyl hydroxylase that controls HIF transcriptional...

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Gepubliceerd in:Cell Metab
Hoofdauteurs: Sim, Jingwei, Cowburn, Andrew S., Palazon, Asis, Madhu, Basetti, Tyrakis, Petros A., Macías, David, Bargiela, David M., Pietsch, Sandra, Gralla, Michael, Evans, Colin E., Kittipassorn, Thaksaon, Chey, Yu C.J., Branco, Cristina M., Rundqvist, Helene, Peet, Daniel J., Johnson, Randall S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887987/
https://ncbi.nlm.nih.gov/pubmed/29617647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.02.020
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