The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia

Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The factor inhibiting HIF (FIH) is an asparaginyl hydroxylase that controls HIF transcriptional...

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Publicat a:Cell Metab
Autors principals: Sim, Jingwei, Cowburn, Andrew S., Palazon, Asis, Madhu, Basetti, Tyrakis, Petros A., Macías, David, Bargiela, David M., Pietsch, Sandra, Gralla, Michael, Evans, Colin E., Kittipassorn, Thaksaon, Chey, Yu C.J., Branco, Cristina M., Rundqvist, Helene, Peet, Daniel J., Johnson, Randall S.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5887987/
https://ncbi.nlm.nih.gov/pubmed/29617647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.02.020
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