Pyrrolysyl-tRNA synthetase:tRNA(Pyl) structure reveals the molecular basis of orthogonality

Pyrrolysine (Pyl), the 22(nd) natural amino acid, is genetically encoded by UAG and inserted into proteins by the unique suppressor tRNA(Pyl)1. The Methanosarcinaceae produce Pyl and express Pyl-containing methyltransferases that allow growth on methylamines2. Homologous methyltransferases and the P...

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Main Authors: Nozawa, Kayo, O’Donoghue, Patrick, Gundllapalli, Sarath, Araiso, Yuhei, Ishitani, Ryuichiro, Umehara, Takuya, Soll, Dieter, Nureki, Osamu
Format: Artigo
Language:Inglês
Published: 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648862/
https://ncbi.nlm.nih.gov/pubmed/19118381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07611
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