The amino-terminal domain of pyrrolysyl-tRNA synthetase is dispensable in vitro but required for in vivo activity

Pyrrolysine (Pyl) is co-translationally inserted into a subset of proteins in the Methanosarcinaceae and in Desulfitobacterium hafniense programmed by an in-frame UAG stop codon. Suppression of this UAG codon is mediated by the Pyl amber suppressor tRNA, tRNA(Pyl), which is aminoacylated with Pyl by...

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Bibliographic Details
Main Authors: Herring, Stephanie, Ambrogelly, Alexandre, Gundllapalli, Sarath, O'Donoghue, Patrick, Polycarpo, Carla R., Söll, Dieter
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074874/
https://ncbi.nlm.nih.gov/pubmed/17582401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.06.004
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