B7-H4–deficient mice display augmented neutrophil-mediated innate immunity

B7-H4 is an immunoglobulin superfamily molecule and shown to be inhibitory for T-cell responses. To explore physiologic roles of B7-H4, we created B7-H4–deficient (KO) mice by genetic targeting. B7-H4KO mice are healthy and their T- and B-cell responses to polyclonal antigens are in normal range. Ho...

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Detalhes bibliográficos
Main Authors: Zhu, Gefeng, Augustine, Mathew M., Azuma, Takeshi, Luo, Liqun, Yao, Sheng, Anand, Sudarshan, Rietz, A. Cecilia, Huang, Jiaqiang, Xu, Haiying, Flies, Andrew S., Flies, Sarah J., Tamada, Koji, Colonna, Marco, van Deursen, Jan M. A., Chen, Lieping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647680/
https://ncbi.nlm.nih.gov/pubmed/19109567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-133223
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