Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice

The mouse Lupo (I282N) mutation in proline-serine-threonine phosphatase–interacting protein 2 (PSTPIP2) leads to reduced expression of PSTPIP2 that is associated with a macrophage-mediated autoinflammatory disease. Another mutation in PSTPIP2, L98P, termed chronic multifocal osteomyelits (cmo), lead...

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Detalhes bibliográficos
Main Authors: Chitu, Violeta, Ferguson, Polly J., de Bruijn, Rosalie, Schlueter, Annette J., Ochoa, Luis A., Waldschmidt, Thomas J., Yeung, Yee-Guide, Stanley, E. Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746474/
https://ncbi.nlm.nih.gov/pubmed/19608749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-204925
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