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An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks

53BP1, the vertebrate ortholog of the budding yeast Rad9 and fission yeast Crb2/Rhp9 checkpoint proteins, is recruited rapidly to sites of DNA double-strand breaks (DSBs). A tandem tudor domain in human 53BP1 that recognizes methylated residues in the histone core is necessary, but not sufficient, f...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zgheib, Omar, Pataky, Kristopher, Brugger, Juergen, Halazonetis, Thanos D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643802/
https://ncbi.nlm.nih.gov/pubmed/19064641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01011-08
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