Structural insight into p53 recognition by the 53BP1 tandem Tudor domain

The tumor suppressor p53 and DNA repair factor 53BP1 regulate gene transcription and responses to genotoxic stresses. Upon DNA damage, p53 undergoes dimethylation at Lys382 (p53K382me2), and this posttranslational modification is recognized by 53BP1. The molecular mechanism of the nonhistone methyll...

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Detalhes bibliográficos
Main Authors: Roy, Siddhartha, Musselman, Catherine A., Kachirskaia, Ioulia, Hayashi, Ryo, Glass, Karen C., Nix, Jay C., Gozani, Or, Appella, Ettore, Kutateladze, Tatiana G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865857/
https://ncbi.nlm.nih.gov/pubmed/20307547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.03.024
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