Structural insight into p53 recognition by the 53BP1 tandem Tudor domain

The tumor suppressor p53 and DNA repair factor 53BP1 regulate gene transcription and responses to genotoxic stresses. Upon DNA damage, p53 undergoes dimethylation at Lys382 (p53K382me2), and this posttranslational modification is recognized by 53BP1. The molecular mechanism of the nonhistone methyll...

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Bibliographic Details
Main Authors:	Roy, Siddhartha, Musselman, Catherine A., Kachirskaia, Ioulia, Hayashi, Ryo, Glass, Karen C., Nix, Jay C., Gozani, Or, Appella, Ettore, Kutateladze, Tatiana G.
Format:	Artigo
Language:	Inglês
Published:	2010
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2865857/ https://ncbi.nlm.nih.gov/pubmed/20307547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.03.024
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Structural insight into p53 recognition by the 53BP1 tandem Tudor domain

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