Structural insight into p53 recognition by the 53BP1 tandem Tudor domain

The tumor suppressor p53 and DNA repair factor 53BP1 regulate gene transcription and responses to genotoxic stresses. Upon DNA damage, p53 undergoes dimethylation at Lys382 (p53K382me2), and this posttranslational modification is recognized by 53BP1. The molecular mechanism of the nonhistone methyll...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Roy, Siddhartha, Musselman, Catherine A., Kachirskaia, Ioulia, Hayashi, Ryo, Glass, Karen C., Nix, Jay C., Gozani, Or, Appella, Ettore, Kutateladze, Tatiana G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865857/
https://ncbi.nlm.nih.gov/pubmed/20307547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.03.024
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares