Glutathione Peroxidase 2, the Major Cigarette Smoke–Inducible Isoform of GPX in Lungs, Is Regulated by Nrf2

Disruption of NF-E2–related factor (Nrf2), a redox-sensitive basic leucine zipper transcription factor, causes early-onset and more severe emphysema due to chronic cigarette smoke. Nrf2 determines the susceptibility of lungs to cigarette smoke–induced emphysema in mice through the transcriptional in...

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Hlavní autoři: Singh, Anju, Rangasamy, Tirumalai, Thimmulappa, Rajesh K., Lee, Hannah, Osburn, William O., Brigelius-Flohé, Regina, Kensler, Thomas W., Yamamoto, Masayuki, Biswal, Shyam
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643293/
https://ncbi.nlm.nih.gov/pubmed/16794261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2005-0325OC
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