Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice

Oxidative stress has been postulated to play an important role in the pathogenesis of asthma; although a defect in antioxidant responses has been speculated to exacerbate asthma severity, this has been difficult to demonstrate with certainty. Nuclear erythroid 2 p45-related factor 2 (Nrf2) is a redo...

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Main Authors: Rangasamy, Tirumalai, Guo, Jia, Mitzner, Wayne A., Roman, Jessica, Singh, Anju, Fryer, Allison D., Yamamoto, Masayuki, Kensler, Thomas W., Tuder, Rubin M., Georas, Steve N., Biswal, Shyam
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212893/
https://ncbi.nlm.nih.gov/pubmed/15998787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050538
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