Interferon-γ Targets Cancer Cells and Osteoclasts to Prevent Tumor-associated Bone Loss and Bone Metastases

Interferon-γ (IFN-γ) has been shown to enhance anti-tumor immunity and inhibit the formation of bone-resorbing osteoclasts. We evaluated the role of IFN-γ in bone metastases, tumor-associated bone destruction, and hypercalcemia in human T cell lymphotrophic virus type 1-Tax transgenic mice. Compared...

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Hlavní autoři: Xu, Zhiqiang, Hurchla, Michelle A., Deng, Hongju, Uluçkan, Özge, Bu, Fang, Berdy, Andrew, Eagleton, Mark C., Heller, Emanuela A., Floyd, Desiree H., Dirksen, Wessel P., Shu, Sherry, Tanaka, Yuetsu, Fernandez, Soledad A., Rosol, Thomas J., Weilbaecher, Katherine N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Molecular Basis of Cell and Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640973/
https://ncbi.nlm.nih.gov/pubmed/19059914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804812200
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