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Thrombospondin-1 regulates bone homeostasis through effects on bone matrix integrity and nitric oxide signaling in osteoclasts

Thrombospondin-1 (TSP1), an endogenous antiangiogenic, is a widely expressed secreted ligand with roles in migration, adhesion and proliferation and is a target for new therapeutics. While TSP1 is present in the bone matrix and several TSP1 receptors play roles in bone biology, the role of TSP1 in b...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Amend, Sarah R., Uluckan, Ozge, Hurchla, Michelle, Leib, Daniel, Novack, Deborah Veis, Silva, Matthew, Frazier, William, Weilbaecher, Katherine N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403870/
https://ncbi.nlm.nih.gov/pubmed/25042340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2308
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