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Hedgehog-targeted therapeutics uncouple the vicious cycle of bone metastasis
Paracrine Hedgehog (Hh) signaling, in which tumor-derived Hh ligands activate stromal cells, has been implicated in the development and progression of many cancers. Recent data suggest that Hh-targeted therapeutics exert direct effects on host cells, thus interrupting a "vicious cycle" to...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518520/ https://ncbi.nlm.nih.gov/pubmed/23243611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.21060 |
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