Interferon-γ Targets Cancer Cells and Osteoclasts to Prevent Tumor-associated Bone Loss and Bone Metastases

Interferon-γ (IFN-γ) has been shown to enhance anti-tumor immunity and inhibit the formation of bone-resorbing osteoclasts. We evaluated the role of IFN-γ in bone metastases, tumor-associated bone destruction, and hypercalcemia in human T cell lymphotrophic virus type 1-Tax transgenic mice. Compared...

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Detalhes bibliográficos
Main Authors: Xu, Zhiqiang, Hurchla, Michelle A., Deng, Hongju, Uluçkan, Özge, Bu, Fang, Berdy, Andrew, Eagleton, Mark C., Heller, Emanuela A., Floyd, Desiree H., Dirksen, Wessel P., Shu, Sherry, Tanaka, Yuetsu, Fernandez, Soledad A., Rosol, Thomas J., Weilbaecher, Katherine N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640973/
https://ncbi.nlm.nih.gov/pubmed/19059914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804812200
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