THE BISPHOSPHONATE ZOLEDRONIC ACID DECREASES TUMOR GROWTH IN BONE IN MICE WITH DEFECTIVE OSTEOCLASTS

Bisphosphonates (BPs), bone targeted drugs that disrupt osteoclast function, are routinely used to treat complications of bone metastasis. Studies in preclinical models of cancer have shown that BPs reduce skeletal tumor burden and increase survival. Similarly, we observed in the present study that...

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Hauptverfasser: Hirbe, Angela C., Roelofs, Anke J., Floyd, Desiree H., Deng, Hongju, Becker, Stephanie N., Lanigan, Lisa G., Apicelli, Anthony J., Xu, Zhiqiang, Prior, Julie L., Eagleton, Mark C., Piwnica-Worms, David, Rogers, Michael J., Weilbaecher, Katherine
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782613/
https://ncbi.nlm.nih.gov/pubmed/19442620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2009.01.010
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