THE BISPHOSPHONATE ZOLEDRONIC ACID DECREASES TUMOR GROWTH IN BONE IN MICE WITH DEFECTIVE OSTEOCLASTS

Bisphosphonates (BPs), bone targeted drugs that disrupt osteoclast function, are routinely used to treat complications of bone metastasis. Studies in preclinical models of cancer have shown that BPs reduce skeletal tumor burden and increase survival. Similarly, we observed in the present study that...

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Detalhes bibliográficos
Main Authors: Hirbe, Angela C., Roelofs, Anke J., Floyd, Desiree H., Deng, Hongju, Becker, Stephanie N., Lanigan, Lisa G., Apicelli, Anthony J., Xu, Zhiqiang, Prior, Julie L., Eagleton, Mark C., Piwnica-Worms, David, Rogers, Michael J., Weilbaecher, Katherine
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782613/
https://ncbi.nlm.nih.gov/pubmed/19442620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2009.01.010
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