RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro

INTRODUCTION: Bisphosphonates are the most widely used class of drug for inhibiting osteoclast-mediated bone loss, but their effectiveness at preventing joint destruction in rheumatoid arthritis has generally been disappointing. We examined whether the ability of bisphosphonates to induce osteoclast...

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Hlavní autoři: Sutherland, Karen A, Rogers, Helena L, Tosh, Denise, Rogers, Michael J
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2009
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688211/
https://ncbi.nlm.nih.gov/pubmed/19405951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2681
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