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Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids

Glucocorticoids depress bone formation by inhibiting osteoblastogenesis and increasing osteoblast apoptosis. However, the role of bone resorption in the initial rapid phase of bone loss characteristic of glucocorticoid-induced osteoporosis is unexplained, and the reason for the efficacy of bisphosph...

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Udgivet i:J Clin Invest
Principais autores: Weinstein, Robert S., Chen, Jin-Ran, Powers, Cara C., Stewart, Scott A., Landes, Reid D., Bellido, Teresita, Jilka, Robert L., Parfitt, A. Michael, Manolagas, Stavros C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC150947/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11956241/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI14538
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