The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling

The adenosine diphosphate (ADP) receptor P2RY12 (purinergic receptor P2Y, G protein coupled, 12) plays a critical role in platelet aggregation, and P2RY12 inhibitors are used clinically to prevent cardiac and cerebral thrombotic events. Extracellular ADP has also been shown to increase osteoclast (O...

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Detalhes bibliográficos
Main Authors: Su, Xinming, Floyd, Desiree H., Hughes, Alun, Xiang, Jingyu, Schneider, Jochen G., Uluckan, Ozge, Heller, Emanuela, Deng, Hongju, Zou, Wei, Craft, Clarissa S., Wu, Kaiming, Hirbe, Angela C., Grabowska, Dorota, Eagleton, Mark C., Townsley, Sarah, Collins, Lynne, Piwnica-Worms, David, Steinberg, Thomas H., Novack, Deborah V., Conley, Pamela B., Hurchla, Michelle A., Rogers, Michael, Weilbaecher, Katherine N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461896/
https://ncbi.nlm.nih.gov/pubmed/22996695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38576
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