RYBP stabilizes p53 by modulating MDM2

The mouse double minute 2 (MDM2)–p53 interaction regulates the activity of p53 and is a potential target for human cancer therapy. Here, we report that RYBP (RING1- and YY1-binding protein), a member of the polycomb group (PcG), interacts with MDM2 and decreases MDM2-mediated p53 ubiquitination, lea...

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Autori principali: Chen, Deng, Zhang, Jianbing, Li, Mao, Rayburn, Elizabeth R, Wang, Hui, Zhang, Ruiwen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
Soggetti:
Scientific Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637313/
https://ncbi.nlm.nih.gov/pubmed/19098711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2008.231
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