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Transcription Factor NFAT1 Activates the mdm2 Oncogene Independent of p53
Although the MDM2-p53 interaction has been well documented, MDM2 overexpression is observed in human cancers with little or no functional p53, suggesting that mdm2 expression is regulated by mechanisms independent of p53. Dysregulation of NFAT signaling is associated with malignant transformation an...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3436296/ https://ncbi.nlm.nih.gov/pubmed/22787160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.373738 |
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