MDM2-NFAT1 Dual Inhibitor, MA242: Effective against Hepatocellular Carcinoma, Independent of p53

The overexpression of the MDM2 oncoprotein frequently occurs in hepatocellular carcinoma (HCC). Small molecules that inhibit MDM2-p53 binding show efficacy against p53 wild-type HCC, but most patients have p53-mutant tumors and intrinsic resistance to such MDM2 inhibitors. We have recently discovere...

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Udgivet i:Cancer Lett
Main Authors: Wang, Wei, Cheng, Jianwen, Qin, Jiang-Jiang, Hu, Bo, Li, Xin, Nijampatnam, Bhavitavya, Velu, Sadanandan E., Fan, Jia, Yang, Xin-Rong, Zhang, Ruiwen
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6650270/
https://ncbi.nlm.nih.gov/pubmed/31181320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2019.114429
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