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Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine
The p53 tumor suppressor plays a major role in controlling the initiation and development of cancer by regulating cell cycle arrest, apoptosis, senescence, and DNA repair. The MDM2 oncogene is a major negative regulator of p53 that inhibits the activity of p53 and reduces its protein stability. MDM2...
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| Publicado en: | Genes Dis |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Chongqing Medical University
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6176154/ https://ncbi.nlm.nih.gov/pubmed/30320185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gendis.2018.07.002 |
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