Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice

To elucidate the pathogenic mechanisms in Huntington's disease (HD) elicited by expression of full-length human mutant huntingtin (fl-mhtt), a bacterial artificial chromosome (BAC)-mediated transgenic mouse model (BACHD) was developed expressing fl-mhtt with 97 glutamine repeats under the contr...

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Main Authors: Gray, Michelle, Shirasaki, Dyna I., Cepeda, Carlos, André, Véronique M., Wilburn, Brian, Lu, Xiao-Hong, Tao, Jifang, Yamazaki, Irene, Li, Shi-Hua, Sun, Yi E., Li, Xiao-Jiang, Levine, Michael S., Yang, X. William
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630800/
https://ncbi.nlm.nih.gov/pubmed/18550760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0857-08.2008
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