Bimodal Recognition of DNA Geometry by Human Topoisomerase IIα: Preferential Relaxation of Positively Supercoiled DNA Requires Elements in the C-Terminal Domain

Human topoisomerase IIα, but not topoisomerase IIβ, can sense the geometry of DNA during relaxation and removes positive supercoils >10-fold faster than it does negative superhelical twists. In contrast, both isoforms maintain lower levels of DNA cleavage intermediates with positively supercoiled...

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Hauptverfasser: McClendon, A. Kathleen, Gentry, Amanda C., Dickey, Jennifer S., Brinch, Marie, Bendsen, Simon, Andersen, Anni H., Osheroff, Neil
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2629653/
https://ncbi.nlm.nih.gov/pubmed/19053267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800453h
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