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Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)

Activation of the p53 tumor suppressor by cellular stress leads to variable responses ranging from growth inhibition to apoptosis. TIGAR is a novel p53-inducible gene that inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate, an activator of glycolysis and inhibitor of glucon...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Li, Hua, Jogl, Gerwald
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2615519/
https://ncbi.nlm.nih.gov/pubmed/19015259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807821200
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